THE ANTICHOLINESTERASE ACTIVITY OF MEFLOQUINE
Identifieur interne : 003509 ( Main/Exploration ); précédent : 003508; suivant : 003510THE ANTICHOLINESTERASE ACTIVITY OF MEFLOQUINE
Auteurs : L. Y. Lim [Singapour] ; M. L. Go [Singapour]Source :
- Clinical and Experimental Pharmacology and Physiology [ 0305-1870 ] ; 1985-10.
English descriptors
- Teeft :
- Agents actions, Amodiaquine, Amopyroquine, Anticholinesterase, Anticholinesterase activity, Antimalarial, Antimalarial drugs, Bche, Biochemical pharmacology, Bulletin world health organisation, Chloroquine, Chloroquine sulphate, Cholinesterase, Concentration range, Diamine oxidase, Dos, Enzyme systems, Histamine methylation, Inhibitory activity, Inhibitory potencies, Medicinal chemistry, Mefloquine, Mefloquine hydrochloride, National university, Ornithine decarboxylase activity, Other antimalarials, Pharmacology, Pharmacy pharmacology, Reaction velocity, Several antimalarials, Side effects, Sigma, Sigma chemical company, Sigma type, Singapore, System disturbances.
Abstract
1. The characteristics of the inhibition of electric eel acetylcholinesterase (AChE) and horse serum butyrylcholinesterase (BChE) by the antimalarial agents mefloquine, chloroquine, amodiaquine and amopyroquine were determined. 2. The antimalarials were found to be non‐competitive inhibitors of both AChE and BChE. In both enzyme systems, inhibitory potencies were in the order amodiaquine > amopyroquine > chloroquine > mefloquine. 3. The low inhibitory potency of mefloquine may account in part for the appearance of gastrointestinal and central nervous system disturbances only at high doses of the drug.
Url:
DOI: 10.1111/j.1440-1681.1985.tb00904.x
Affiliations:
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Le document en format XML
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Y." last="Lim">L. Y. Lim</name><affiliation wicri:level="4"><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Pharmacy, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Go, M L" sort="Go, M L" uniqKey="Go M" first="M. L." last="Go">M. L. Go</name><affiliation wicri:level="4"><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Pharmacy, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation><affiliation wicri:level="4"><orgName type="university">Université nationale de Singapour</orgName><country>Singapour</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical and Experimental Pharmacology and Physiology</title><title level="j" type="alt">CLINICAL EXPERIMENTAL PHARMACOLOGY PHYSIOLOGY</title><idno type="ISSN">0305-1870</idno><idno type="eISSN">1440-1681</idno><imprint><biblScope unit="vol">12</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="527">527</biblScope><biblScope unit="page" to="531">531</biblScope><biblScope unit="page-count">5</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1985-10">1985-10</date></imprint><idno type="ISSN">0305-1870</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0305-1870</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Agents actions</term><term>Amodiaquine</term><term>Amopyroquine</term><term>Anticholinesterase</term><term>Anticholinesterase activity</term><term>Antimalarial</term><term>Antimalarial drugs</term><term>Bche</term><term>Biochemical pharmacology</term><term>Bulletin world health organisation</term><term>Chloroquine</term><term>Chloroquine sulphate</term><term>Cholinesterase</term><term>Concentration range</term><term>Diamine oxidase</term><term>Dos</term><term>Enzyme systems</term><term>Histamine methylation</term><term>Inhibitory activity</term><term>Inhibitory potencies</term><term>Medicinal chemistry</term><term>Mefloquine</term><term>Mefloquine hydrochloride</term><term>National university</term><term>Ornithine decarboxylase activity</term><term>Other antimalarials</term><term>Pharmacology</term><term>Pharmacy pharmacology</term><term>Reaction velocity</term><term>Several antimalarials</term><term>Side effects</term><term>Sigma</term><term>Sigma chemical company</term><term>Sigma type</term><term>Singapore</term><term>System disturbances</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">1. The characteristics of the inhibition of electric eel acetylcholinesterase (AChE) and horse serum butyrylcholinesterase (BChE) by the antimalarial agents mefloquine, chloroquine, amodiaquine and amopyroquine were determined. 2. The antimalarials were found to be non‐competitive inhibitors of both AChE and BChE. In both enzyme systems, inhibitory potencies were in the order amodiaquine > amopyroquine > chloroquine > mefloquine. 3. The low inhibitory potency of mefloquine may account in part for the appearance of gastrointestinal and central nervous system disturbances only at high doses of the drug.</div></front></TEI><affiliations><list><country><li>Singapour</li></country><orgName><li>Université nationale de Singapour</li></orgName></list><tree><country name="Singapour"><noRegion><name sortKey="Lim, L Y" sort="Lim, L Y" uniqKey="Lim L" first="L. Y." last="Lim">L. Y. Lim</name></noRegion><name sortKey="Go, M L" sort="Go, M L" uniqKey="Go M" first="M. L." last="Go">M. L. Go</name><name sortKey="Go, M L" sort="Go, M L" uniqKey="Go M" first="M. L." last="Go">M. L. Go</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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